Seeing the light

 作者:利泾荷     |      日期:2019-03-06 04:06:08
VISION has been restored to mice with a disorder that also affects humans. A mutation in the Rpe65 gene means that people with Leber congenital amaurosis can’t metabolise vitamin A. This blocks the biochemical pathway that restores the retina’s photopigments after they have been struck by light and causes the retina to degenerate, leading to blindness. In a forthcoming issue of Proceedings of the National Academy of Sciences, Preston Van Hooser of the University of Washington in Seattle and his colleagues report that by feeding two-month-old mice the vitamin A derivative 9-cis-retinal,